Razmkhah Mahboobeh, Talei Abdul-Rasoul, Doroudchi Mehrnoosh, Khalili-Azad Tahereh, Ghaderi Abbas
Department of Immunology, Shiraz University of Medical Sciences, P.O. Box 71345-319, Shiraz, Iran.
Cancer Lett. 2005 Jul 28;225(2):261-6. doi: 10.1016/j.canlet.2004.10.039. Epub 2004 Dec 13.
Stromal cell-Derived Factor-1 (SDF-1, CXCL12) is one the ELR- CXC angiogenic chemokines. It contributes to hematopoiesis and lymphocyte trafficking. SDF-1 and its exclusive receptor, CXCR4, are reported to play important roles in tumor growth, angiogenesis and metastasis of different types of tumors such as breast, lung, prostate and pancreatic cancers. SDF-1 gene polymorphism, known as SDF1-3'A, has been investigated in HIV-1 infection and the incidence of breast cancer. This investigation was aimed to study the frequency of SDF1-3'A mutation in Iranian women with breast cancer. Results showed that the frequency of AA and AG genotypes was higher among patients, while the frequency of GG genotype was lower compared to the controls. Thus AA and AG genotypes of SDF-1 may be considered as factors increasing the susceptibility of Iranian women to breast cancer.
基质细胞衍生因子-1（SDF-1，CXCL12）是ELR-CXC血管生成趋化因子之一。它有助于造血和淋巴细胞运输。据报道，SDF-1及其唯一受体CXCR4在乳腺癌、肺癌、前列腺癌和胰腺癌等不同类型肿瘤的生长、血管生成和转移中发挥重要作用。SDF-1基因多态性，即SDF1-3'A，已在HIV-1感染和乳腺癌发病率方面进行了研究。本研究旨在探讨伊朗乳腺癌女性中SDF1-3'A突变的频率。结果显示，患者中AA和AG基因型的频率较高，而GG基因型的频率低于对照组。因此，SDF-1的AA和AG基因型可能被视为增加伊朗女性患乳腺癌易感性的因素。
