Ashizuka Shinya, Ishikawa Naoto, Kato Johji, Yamaga Junichi, Inatsu Haruhiko, Eto Tanenao, Kitamura Kazuo
First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan.
Peptides. 2005 Dec;26(12):2610-5. doi: 10.1016/j.peptides.2005.05.007. Epub 2005 Jun 23.
Adrenomedullin (AM) administered intracolonically ameliorated the severity of acetic acid-induced colonic ulceration in rats. Ulcers were induced by subserosal injection of acetic acid into the colon. AM-treated group was administered 0.25-1.0 microg of AM in 0.5 ml of saline intracolonically once a day; the control group received only saline. AM administration dose-dependently and significantly reduced the size of the ulcerative lesions, the associated edema, and the infiltration of the affected area by inflammatory cells. AM also reduced tissue levels of interleukin-6, but not interferon-gamma. AM reduces the severity of acetic acid-induced colitis in rats, probably by inhibiting the production and/or release of Th-2 cell-derived factors such as interleukin-6.
结肠内给予肾上腺髓质素（AM）可减轻大鼠乙酸诱导的结肠溃疡严重程度。通过向结肠浆膜下注射乙酸诱导溃疡。AM治疗组每天一次结肠内给予0.5 ml盐水中含0.25 - 1.0微克的AM；对照组仅接受盐水。AM给药剂量依赖性且显著地减小了溃疡性病变的大小、相关水肿以及炎症细胞对受累区域的浸润。AM还降低了白细胞介素-6的组织水平，但未降低干扰素-γ的水平。AM可能通过抑制Th-2细胞衍生因子如白细胞介素-6的产生和/或释放来减轻大鼠乙酸诱导的结肠炎的严重程度。
