Pueyo Jose Ignacio, Couso Juan Pablo
School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK.
Curr Opin Genet Dev. 2005 Aug;15(4):439-46. doi: 10.1016/j.gde.2005.06.007.
Evolutionary studies suggest that the limbs of vertebrates and the appendages of arthropods do not share a common origin. However, recent genetic studies show new similarities in their developmental programmes. These similarities might be caused by the independent recruitment of homologous genes for similar functions or by the conservation of an ancestral proximal-distal development programme. This basic programme might have arisen in an ancestral outgrowth and been independently co-opted in vertebrate and arthropod appendages. It has subsequently diverged in both phyla to fine-pattern the limb and to control phylum-specific cellular events. We suggest that although vertebrate limbs and arthropod appendages are not strictly homologous structures they retain remnants of a common ancestral developmental programme.
进化研究表明，脊椎动物的四肢与节肢动物的附肢并非起源相同。然而，最近的基因研究显示出它们在发育程序上有新的相似之处。这些相似性可能是由于为相似功能独立招募了同源基因，或者是由于祖先近端 - 远端发育程序的保守性。这个基本程序可能起源于一个祖先的突出物，并在脊椎动物和节肢动物的附肢中被独立地采用。随后，它在两个门中都发生了分化，以细化肢体模式并控制门特异性的细胞事件。我们认为，尽管脊椎动物的四肢和节肢动物的附肢并非严格同源结构，但它们保留了共同祖先发育程序的残余部分。
