脊椎动物发育中的微小RNA

MicroRNAs in vertebrate development.

作者信息

Harfe Brian D

机构信息

Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, PO Box 100266, Gainesville, FL 32610, USA.

出版信息

Curr Opin Genet Dev. 2005 Aug;15(4):410-5. doi: 10.1016/j.gde.2005.06.012.

DOI:10.1016/j.gde.2005.06.012

PMID:15979303

Abstract

The vertebrate genome contains hundreds of small non-coding 'microRNAs' that have been implicated in controlling the expression of potentially thousands of target genes. Presently, only a handful of these targets have been characterized. Recent reports of microRNA 'sensors', microRNA microarrays and the creation of vertebrates that lack all microRNA activity will aid in determining the roles played by microRNAs, and the genes that they regulate, during vertebrate development.

摘要

脊椎动物基因组包含数百种小的非编码“微小RNA”，这些微小RNA与控制潜在的数千个靶基因的表达有关。目前，只有少数这些靶基因得到了表征。最近关于微小RNA“传感器”、微小RNA微阵列以及缺乏所有微小RNA活性的脊椎动物的报道，将有助于确定微小RNA及其调控的基因在脊椎动物发育过程中所起的作用。