Ambros Victor
Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA.
Cell. 2003 Jun 13;113(6):673-6. doi: 10.1016/s0092-8674(03)00428-8.
Drosophila geneticists have uncovered roles for microRNAs in the coordination of cell proliferation and cell death during development, and in stress resistance and fat metabolism. In C. elegans, a homolog of the well-known fly developmental regulator hunchback acts downstream of the microRNAs lin-4 and let-7 in a pathway controlling developmental timing.
果蝇遗传学家已经揭示了微小RNA在发育过程中细胞增殖与细胞死亡的协调作用，以及在抗逆性和脂肪代谢中的作用。在秀丽隐杆线虫中，著名的果蝇发育调节因子驼背蛋白的一个同源物，在控制发育时间的一条信号通路中，作用于微小RNA lin-4和let-7的下游。
