Nyberg Sigrid, Andersson Agneta, Zingmark Elisabeth, Wahlström Göran, Bäckström Torbjörn, Sundström-Poromaa Inger
Department of Clinical Science, Obstetrics and Gynecology, University Hospital of Umeå, Umeå University, Sweden.
Psychoneuroendocrinology. 2005 Oct;30(9):892-901. doi: 10.1016/j.psyneuen.2005.04.016.
Neurosteroids have been proposed to play an important role in the interaction between alcohol and GABA(A) receptors and for the symptomatology of premenstrual dysphoric disorder (PMDD). The primary aim of this study was to investigate possible alcohol-induced changes in allopregnanolone serum concentrations across different menstrual cycle phases in women with severe premenstrual syndrome (PMS) and controls.
The allopregnanolone and cortisol responses to a low-dose of alcohol were evaluated in 14 women with and 12 women without severe premenstrual syndrome in the follicular and late luteal phases. The effect of a 30-min intravenous alcohol infusion (0.2 g/kg) on allopregnanolone and cortisol serum concentrations was compared to placebo, and compared between cycle phases and groups. Blood samples for measuring allopregnanolone were taken at baseline 25, 55, and 75 min after the start of the alcohol infusion.
In the late luteal phase, the alcohol infusion decreased allopregnanolone levels, compared to baseline levels as well as to placebo. The difference in allopregnanolone levels between alcohol and placebo was evident 25 min (P < 0.01), 55 min (P < 0.01), and 75 min (P < 0.05) after start of the infusion. There was no change in allopregnanolone levels during the alcohol infusion in the follicular phase. Also, no difference in alcohol-induced allopregnanolone response between PMS patients and control subjects was detected. Cortisol levels declined during both the placebo and alcohol infusion, but did not differ with respect to which infusion had been given.
During the late luteal phase, independent of PMS diagnosis, the low-dose alcohol infusion resulted in decreasing peripheral allopregnanolone levels.
神经甾体被认为在酒精与γ-氨基丁酸A（GABA(A)）受体的相互作用以及经前烦躁障碍（PMDD）的症状学中发挥重要作用。本研究的主要目的是调查患有严重经前综合征（PMS）的女性和对照组在不同月经周期阶段，酒精诱导的孕烷醇酮血清浓度可能发生的变化。
在卵泡期和黄体晚期，对14名患有严重经前综合征的女性和12名未患严重经前综合征的女性进行了低剂量酒精的孕烷醇酮和皮质醇反应评估。将30分钟静脉输注酒精（0.2 g/kg）对孕烷醇酮和皮质醇血清浓度的影响与安慰剂进行比较，并在不同周期阶段和组间进行比较。在酒精输注开始后的基线、25分钟、55分钟和75分钟采集用于测量孕烷醇酮的血样。
在黄体晚期，与基线水平和安慰剂相比，酒精输注降低了孕烷醇酮水平。酒精与安慰剂之间孕烷醇酮水平的差异在输注开始后25分钟（P < 0.01）、55分钟（P < 0.01）和75分钟（P < 0.05）时明显。卵泡期酒精输注期间孕烷醇酮水平没有变化。此外，未检测到PMS患者和对照受试者之间酒精诱导的孕烷醇酮反应存在差异。安慰剂和酒精输注期间皮质醇水平均下降，但在输注何种药物方面没有差异。
在黄体晚期，与PMS诊断无关，低剂量酒精输注导致外周孕烷醇酮水平降低。
