别孕烯醇酮对经前烦躁障碍患者或健康对照者的惊吓反应及惊吓反应的前脉冲抑制均无影响。
Allopregnanolone has no effect on startle response and prepulse inhibition of startle response in patients with premenstrual dysphoric disorder or healthy controls.
作者信息
Kask Kristiina, Bäckström Torbjörn, Lundgren Per, Sundström Poromaa Inger
机构信息
Department Women's and Children's Health, Uppsala University, Uppsala, Sweden.
出版信息
Pharmacol Biochem Behav. 2009 Jun;92(4):608-13. doi: 10.1016/j.pbb.2009.02.014. Epub 2009 Mar 4.
BACKGROUND
Allopregnanolone is an endogenous neuroactive steroid which, through the binding to the GABA(A) receptor, enhances inhibitory neurotransmission and exerts anxiolytic, sedative and antiepileptic effects. Following acute administration, allopregnanolone reliably acts as an anxiolytic compound. The primary aim of this study was to investigate if allopregnanolone, administered to healthy women and women with premenstrual dysphoric disorder (PMDD), would have an anxiolytic effect, expressed as a decreased startle response.
MATERIALS AND METHODS
Sixteen PMDD patients and twelve healthy controls completed the study. The participants were scheduled for the startle tests twice in the luteal phase. During the test sessions an intravenous allopregnanolone and placebo bolus injection was administered in double-blinded, randomized order at intervals of 48 h. Following the allopregnanolone/placebo injections startle response and prepulse inhibition of startle response (PPI) were assessed by electromyography.
RESULTS
Following the intravenous allopregnanolone administration the serum concentrations of allopregnanolone increased to 50-70 nmol/l, corresponding to levels that are seen during pregnancy. The obtained serum concentrations of allopregnanolone were significantly lower in PMDD patients than among the healthy controls, p<0.05. The allopregnanolone injection resulted in significant increases of self-rated sedation in both groups, p<0.01. Allopregnanolone did not induce any changes in startle response or prepulse inhibition of startle response in comparison to placebo. No differences in allopregnanolone-induced changes in startle response or PPI could be detected between PMDD patients and controls subjects.
CONCLUSION
Startle response and PPI were unaffected by acute intravenous administration of allopregnanolone in PMDD patients and healthy controls.
背景
别孕烯醇酮是一种内源性神经活性甾体，通过与γ-氨基丁酸A（GABA(A)）受体结合，增强抑制性神经传递，并发挥抗焦虑、镇静和抗癫痫作用。急性给药后，别孕烯醇酮可可靠地作为一种抗焦虑化合物。本研究主要目的是调查给予健康女性和经前烦躁障碍（PMDD）女性别孕烯醇酮是否会产生抗焦虑作用，表现为惊吓反应降低。
材料与方法
16例PMDD患者和12例健康对照完成了本研究。参与者在黄体期安排进行两次惊吓测试。在测试期间，以双盲、随机顺序每隔48小时静脉注射一次别孕烯醇酮和安慰剂大剂量注射剂。在注射别孕烯醇酮/安慰剂后，通过肌电图评估惊吓反应和惊吓反应的预脉冲抑制（PPI）。
结果
静脉注射别孕烯醇酮后，别孕烯醇酮的血清浓度增加至50 - 70 nmol/L，与孕期所见水平相当。PMDD患者中获得的别孕烯醇酮血清浓度显著低于健康对照，p<0.05。别孕烯醇酮注射导致两组自我评定的镇静程度显著增加，p<0.01。与安慰剂相比，别孕烯醇酮未引起惊吓反应或惊吓反应的预脉冲抑制有任何变化。在PMDD患者和对照受试者之间，未检测到别孕烯醇酮引起的惊吓反应或PPI变化存在差异。
结论
在PMDD患者和健康对照中，急性静脉注射别孕烯醇酮未影响惊吓反应和PPI。
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