Miller Juli P, Allman David
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 269 John Morgan Building, 36th and Hamilton Walk, Philadelphia, PA 19104, USA.
Semin Immunol. 2005 Oct;17(5):321-9. doi: 10.1016/j.smim.2005.05.003.
B cell genesis declines with age, but at what stage and why remains unclear. Previous studies attribute the decline in B cell production in aged mice to both environmental and cell-intrinsic defects that impact mid-to-late stream B cell precursors. However, mounting evidence suggests that the aging process may also negatively affect the earliest phases of B cell development. We review past studies on the B cells and aging question, discuss recent data suggesting that age-associated defects in B cell development reflect deficiencies in hematopoietic stem cell-proximal progenitor pools, and provide an integrative model that will hopefully facilitate further studies into this complex problem.
B细胞生成随年龄增长而减少，但具体在哪个阶段以及原因尚不清楚。以往的研究将老年小鼠B细胞产生的减少归因于影响中晚期B细胞前体的环境和细胞内在缺陷。然而，越来越多的证据表明，衰老过程也可能对B细胞发育的最早阶段产生负面影响。我们回顾了过去关于B细胞与衰老问题的研究，讨论了最近的数据，这些数据表明B细胞发育中与年龄相关的缺陷反映了造血干细胞近端祖细胞池的不足，并提供了一个综合模型，有望促进对这个复杂问题的进一步研究。
