分散于多孔可生物降解聚（ε-己内酯）微粒中的万古霉素的体外和体内杀菌活性
In vitro and in vivo bactericidal activities of vancomycin dispersed in porous biodegradable poly(epsilon-caprolactone) microparticles.
作者信息
Le Ray Anne-Marie, Gautier Hélène, Laty Marie-Katel, Daculsi Guy, Merle Christian, Jacqueline Cédric, Hamel Antoine, Caillon Jocelyne
机构信息
Centre de Recherche sur les Matériaux d'Intérêt Biologique, Equipe INSERM 99-03, UFR Odontologie, University of Nantes, 1 rue Gaston Veil, 44035 Nantes, France.
出版信息
Antimicrob Agents Chemother. 2005 Jul;49(7):3025-7. doi: 10.1128/AAC.49.7.3025-3027.2005.
Abstract
Treatment of methicillin-resistant Staphylococcus aureus osteomyelitis requires a prolonged antibiotic therapy with vancomycin. Because of its weak diffusion, the in situ implantation of vancomycin could be interesting. The activity of vancomycin encapsulated in microparticles was evaluated in vitro and in vivo on rabbit osteomyelitis and showed a good activity compared to intravenous administration.
摘要
耐甲氧西林金黄色葡萄球菌骨髓炎的治疗需要用万古霉素进行长期抗生素治疗。由于其扩散性较弱，万古霉素的原位植入可能会很有意义。对包裹在微粒中的万古霉素的活性在体外以及在兔骨髓炎模型上进行了体内评估，结果显示与静脉给药相比其活性良好。
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