在耐甲氧西林金黄色葡萄球菌兔骨髓炎实验模型中体内评估缺钙磷灰石万古霉素药物输送系统的抗菌活性。
In vivo assessment of the antimicrobial activity of a calcium-deficient apatite vancomycin drug delivery system in a methicillin-resistant Staphylococcus aureus rabbit osteomyelitis experimental model.
机构信息
CHU de Nantes, 1 Rue Gaston Veil, 44035 Nantes, France.
出版信息
Antimicrob Agents Chemother. 2010 Feb;54(2):950-2. doi: 10.1128/AAC.00434-09. Epub 2009 Nov 23.
Abstract
The antimicrobial activities of calcium-deficient apatite loaded with different concentrations (25, 100, and 500 microg/mg) of vancomycin as a filling biomaterial were evaluated in a methicillin-resistant Staphylococcus aureus (MRSA) rabbit acute osteomyelitis model. Bacterial counts in bone, bone marrow, and joint fluid samples treated with forms of the apatite were compared to those in tissue samples receiving a constant intravenous vancomycin infusion after 4 days. This study demonstrates that using a calcium-deficient apatite loaded with vancomycin dramatically decreases the bacterial counts in bone and marrow.
摘要
将不同浓度（25、100 和 500μg/mg）万古霉素负载于缺钙磷灰石作为填充生物材料，评估其在耐甲氧西林金黄色葡萄球菌（MRSA）兔急性骨髓炎模型中的抗微生物活性。比较用各种形式的磷灰石处理的骨、骨髓和关节液样本中的细菌计数与在第 4 天接受恒定静脉万古霉素输注的组织样本中的细菌计数。本研究表明，使用负载万古霉素的缺钙磷灰石可显著降低骨和骨髓中的细菌计数。
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