Maiti Rajarshi, Van Domselaar Gary H, Wishart David S
Department of Computing Science, University of Alberta, Edmonton, AB, Canada T6G 2E8.
Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W358-62. doi: 10.1093/nar/gki485.
MovieMaker is a web server that allows short ( approximately 10 s), downloadable movies of protein motions to be generated. It accepts PDB files or PDB accession numbers as input and automatically calculates, renders and merges the necessary image files to create colourful animations covering a wide range of protein motions and other dynamic processes. Users have the option of animating (i) simple rotation, (ii) morphing between two end-state conformers, (iii) short-scale, picosecond vibrations, (iv) ligand docking, (v) protein oligomerization, (vi) mid-scale nanosecond (ensemble) motions and (vii) protein folding/unfolding. MovieMaker does not perform molecular dynamics calculations. Instead it is an animation tool that uses a sophisticated superpositioning algorithm in conjunction with Cartesian coordinate interpolation to rapidly and automatically calculate the intermediate structures needed for many of its animations. Users have extensive control over the rendering style, structure colour, animation quality, background and other image features. MovieMaker is intended to be a general-purpose server that allows both experts and non-experts to easily generate useful, informative protein animations for educational and illustrative purposes. MovieMaker is accessible at http://wishart.biology.ualberta.ca/moviemaker.
MovieMaker是一个网络服务器，它能够生成时长较短（约10秒）、可下载的蛋白质运动影片。它接受PDB文件或PDB登录号作为输入，并自动计算、渲染和合并必要的图像文件，以创建涵盖各种蛋白质运动及其他动态过程的彩色动画。用户可以选择对以下内容进行动画制作：（i）简单旋转；（ii）两个终态构象之间的变形；（iii）短尺度的皮秒级振动；（iv）配体对接；（v）蛋白质寡聚化；（vi）中尺度的纳秒级（整体）运动；以及（vii）蛋白质折叠/去折叠。MovieMaker不进行分子动力学计算。相反，它是一个动画工具，使用复杂的叠加算法结合笛卡尔坐标插值来快速自动计算其许多动画所需的中间结构。用户可以对渲染风格、结构颜色、动画质量、背景及其他图像特征进行广泛控制。MovieMaker旨在成为一个通用服务器，使专家和非专家都能轻松生成用于教育和说明目的的有用、信息丰富的蛋白质动画。可通过http://wishart.biology.ualberta.ca/moviemaker访问MovieMaker。
