Tsujimaru S, Ida Y, Satoh H, Egami H, Shirao I, Mukasa H, Nakazawa Y
Department of Neuropsychiatry, Kurume University School of Medicine, Japan.
Life Sci. 1992;50(24):1843-50. doi: 10.1016/0024-3205(92)90544-y.
The effects of methyl vitamin B12 (5-6 mg/kg, p.o.) on the entrainment of circadian running wheel activity rhythm to a new lighting schedule were measured in rats. After the light-dark (LD) cycle was abruptly reversed, rats given vitamin B12 took less time to entrain their circadian locomotor activity rhythm to the new cycle than did controls. This result indicates that vitamin B12 accelerates the reentrainment of the mammalian circadian activity rhythm following an abrupt change in the environmental LD cycle.
在大鼠中测量了甲基维生素B12（5-6毫克/千克，口服）对昼夜节律性跑步轮活动节律与新光照时间表同步的影响。在明暗（LD）周期突然逆转后，给予维生素B12的大鼠比对照组花费更少的时间将其昼夜运动活动节律与新周期同步。这一结果表明，维生素B12可加速环境LD周期突然变化后哺乳动物昼夜活动节律的重新同步。
