Yang Lijian, Jia Ya
Department of Physics and Institute of Biophysics, Central China Normal University, Wuhan 430079, PR China.
Biosystems. 2005 Sep;81(3):267-80. doi: 10.1016/j.biosystems.2005.05.004.
Based on the Hodgkin-Huxley (HH) model, the effects of patch temperature as a control parameter on the spontaneous action potentials for finite size of membrane patch are studied. With increasing patch temperature, it is found that the mean open rates of sodium and potassium channels of the HH neuron are decreased, and the mean duration of spikes of membrane potential is also decreased, which are qualitatively consistent with previous experimental results of single ion channel. Under moderate patch size, the mean interspike interval of membrane potential first decreases, reaches a minimum, and then increases with increasing patch temperature. It is shown that for both low and high temperatures, the channels fluctuation-induced spontaneous action potentials appear to be rather irregular, while for moderate patch temperature, relatively coherent oscillations observed. By defining a measure parameter beta, we show that there is a maximal region for the measure beta in the patch temperature and patch size parameter plane where the coherence resonance phenomena are very remarkable, and the characteristic correlation time of the output also confirm our result.
基于霍奇金-赫胥黎（HH）模型，研究了作为控制参数的膜片温度对有限大小膜片自发动作电位的影响。随着膜片温度升高，发现HH神经元的钠通道和钾通道的平均开放率降低，膜电位尖峰的平均持续时间也缩短，这在定性上与先前单离子通道的实验结果一致。在适中的膜片大小下，膜电位的平均峰间间隔先减小，达到最小值，然后随着膜片温度升高而增大。结果表明，在低温和高温时，通道波动诱发的自发动作电位显得相当不规则，而在适中的膜片温度下，可观察到相对相干的振荡。通过定义一个测量参数β，我们表明在膜片温度和膜片大小参数平面中存在一个测量β的最大区域，其中相干共振现象非常显著，并且输出的特征相关时间也证实了我们的结果。
