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Cardiac glycosides inhibit TNF-alpha/NF-kappaB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor.
Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9631-6. doi: 10.1073/pnas.0504097102. Epub 2005 Jun 27.
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Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected].
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Protein Kinase-Mediated Decision Between the Life and Death.
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Cardiac glycosides: Looking beyond heart failure and atrial fibrillation.
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Drug target of natural products and COVID-19: how far has science progressed?
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Digoxin mitigates diethylnitrosamine-induced acute liver injury in mice via limiting production of inflammatory mediators.
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A review on potential of natural products in the management of COVID-19.
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Blocking TNF signaling may save lives in COVID-19 infection.
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Cardiac Glycosides as Autophagy Modulators.
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IkappaB kinase is an essential component of the Tpl2 signaling pathway.
Mol Cell Biol. 2004 Jul;24(13):6040-8. doi: 10.1128/MCB.24.13.6040-6048.2004.
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Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cells.
Proc Natl Acad Sci U S A. 2004 May 18;101(20):7693-8. doi: 10.1073/pnas.0402030101. Epub 2004 May 10.
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Multiple control of interleukin-8 gene expression.
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Nuclear transcription factor-kappaB as a target for cancer drug development.
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TNF-R1 signaling: a beautiful pathway.
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NFkappaB-dependent signaling pathways.
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The essential role of MEKK3 in TNF-induced NF-kappaB activation.
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Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells.
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