释放一氧化氮的金纳米颗粒的合成

Synthesis of nitric oxide-releasing gold nanoparticles.

作者信息

Rothrock Aaron R, Donkers Robert L, Schoenfisch Mark H

机构信息

Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

出版信息

J Am Chem Soc. 2005 Jul 6;127(26):9362-3. doi: 10.1021/ja052027u.

DOI:10.1021/ja052027u

PMID:15984851

Abstract

We report the synthesis of nitric oxide-releasing gold nanoparticles formed by place-exchange reaction of hexanethiol monolayer-protected clusters with diamine nitric oxide donor precursor molecules, which are subsequently converted to N-diazeniumdiolate NO donors. The nitric oxide release from the N-diazeniumdiolate-modified gold nanoparticles is tunable by varying the number and/or the chemical structure of the exchanged amine ligands. The size and stability of NO-releasing nanoparticles may prove useful for a range of biomedical and pharmaceutical applications.

摘要

我们报道了通过己硫醇单层保护簇与二胺一氧化氮供体前体分子的位置交换反应形成的一氧化氮释放金纳米颗粒的合成，这些前体分子随后被转化为N-二氮烯二醇盐一氧化氮供体。通过改变交换的胺配体的数量和/或化学结构，可以调节N-二氮烯二醇盐修饰的金纳米颗粒释放一氧化氮的过程。释放一氧化氮的纳米颗粒的尺寸和稳定性可能对一系列生物医学和制药应用有用。