Asplund R
Center for Public Health, Karolinska Institutet, SE 141 83 Huddinge, Sweden.
Arch Gerontol Geriatr. 2005 Nov-Dec;41(3):255-60. doi: 10.1016/j.archger.2005.04.003. Epub 2005 Jun 27.
The aim of this study was to assess the relationship between BMS and nocturnal micturition in a group of elderly men and women. The study comprised 6103 elderly men and women recruited from a group of pensioners by means of a questionnaire (n=10,216; response rate 61.3%). The mean (+/-S.D.) ages of the men and women were 73.0+/-6.0 years and 72.6+/-6.7 years, respectively. The questionnaire included questions on their health, diseases and symptoms, drugs, sleep habits and the number of nocturnal voiding episodes. BMS was reported by 2.4% of the men and 8.5% of the women (p<0.0001). The occurrence of BMS was unaffected by age in both sexes. In women, but not in men, there was a stepwise increase in BMS in parallel with increased nocturnal micturition. There was a strong relation between nocturnal thirst and drinking on the one hand, and reports on BMS on the other hand. BMS was also increased in diuretics users in both sexes. The results may indicate that negative fluid balance as a consequence of nocturnal polyuria is an overlooked pathogenetic mechanism in the genesis of BMS in the elderly.
本研究旨在评估一组老年男性和女性中膀胱过度活动症（BMS）与夜间排尿之间的关系。该研究通过问卷调查从一组退休人员中招募了6103名老年男性和女性（n = 10216；应答率61.3%）。男性和女性的平均（±标准差）年龄分别为73.0±6.0岁和72.6±6.7岁。问卷包括有关他们的健康状况、疾病和症状、药物、睡眠习惯以及夜间排尿次数的问题。报告有膀胱过度活动症的男性占2.4%，女性占8.5%（p<0.0001）。膀胱过度活动症的发生在两性中均不受年龄影响。在女性中，而非男性中，随着夜间排尿次数增加，膀胱过度活动症呈逐步上升趋势。夜间口渴与饮水一方面与膀胱过度活动症报告另一方面之间存在密切关系。两性中使用利尿剂者的膀胱过度活动症也有所增加。结果可能表明，夜间多尿导致的负水平衡是老年人膀胱过度活动症发生过程中一个被忽视的发病机制。
