用于人类正电子发射断层显像（PET）成像研究的多巴胺转运体配体[(18)F]FECNT的半自动制备
Semi-automated preparation of the dopamine transporter ligand [(18)F]FECNT for human PET imaging studies.
作者信息
Voll Ronald J, McConathy Jonathan, Waldrep Michael S, Crowe Ronald J, Goodman Mark M
机构信息
Department of Radiology, EUH, 1364 Clifton Road NE, Atlanta, GA 30322, USA.
出版信息
Appl Radiat Isot. 2005 Sep;63(3):353-61. doi: 10.1016/j.apradiso.2005.04.008.
The fluorine-18 labeled dopamine transport (DAT) ligand 2 beta-carbomethoxy-3beta-(4-chlorophenyl)-8-(2-fluoroethyl)nortropane (FECNT) has shown promising properties as an in vivo DAT imaging agent in human and monkey PET studies. A semi-automated synthesis has been developed to reliably produce [(18)F]FECNT in a 16% decay corrected yield. This method utilizes a new [(18)F]fluoralkylating agent and provides high purity [(18)F]FECNT in a formulation suitable for human use.
氟-18标记的多巴胺转运体（DAT）配体2β-甲氧羰基-3β-（4-氯苯基）-8-（2-氟乙基）去甲托烷（FECNT）在人体和猴子的正电子发射断层扫描（PET）研究中已显示出作为一种体内DAT成像剂的良好特性。已开发出一种半自动合成方法，以16%的衰变校正产率可靠地生产[(18)F]FECNT。该方法使用一种新的[(18)F]氟烷基化剂，并以适合人体使用的制剂形式提供高纯度的[(18)F]FECNT。
Zotero 插件