抑郁症与帕金森病患者的日常生活活动能力受损有关，而非运动功能受损。

Depression is associated with impairment of ADL, not motor function in Parkinson disease.

作者信息

Holroyd Suzanne, Currie Lillian J, Wooten G Frederick

机构信息

Department of Psychiatric Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA.

出版信息

Neurology. 2005 Jun 28;64(12):2134-5. doi: 10.1212/01.WNL.0000165958.12724.0D.

DOI:10.1212/01.WNL.0000165958.12724.0D

PMID:15985588

Abstract

Depression was diagnosed in 15% of 100 consecutive patients with Parkinson disease (PD). Depression was associated with lower cognition, history of depression, and a higher Unified Parkinson's Disease Rating Scale score. The latter was due to differences in the activities of daily living (ADL) subscale (17 +/- 7 vs 12 +/- 6; p = 0.004) rather than the motor subscale (30 +/- 13 vs 26 +/- 13; p = 0.27). These results suggest that ADL impairment may in part be due to depression. Patients with PD with poor function should be closely evaluated for depression.

摘要

在连续的100例帕金森病（PD）患者中，15%被诊断出患有抑郁症。抑郁症与较低的认知能力、抑郁症病史以及较高的统一帕金森病评定量表得分相关。后者是由于日常生活活动（ADL）子量表存在差异（17±7 vs 12±6；p = 0.004），而非运动子量表（30±13 vs 26±13；p = 0.27）。这些结果表明，ADL受损可能部分归因于抑郁症。功能较差的PD患者应密切评估是否患有抑郁症。