Easmon C S, Glynn A A
Immunology. 1979 Sep;38(1):103-8.
The cells which suppressed delayed hypersensitivity (DH) to Staphylococcus aureus in the mice were non-phagocytic, adhered to nylon wool and possessed surface immunoglobulin but no detectable Thy 1. antigen. They were probably B lymphocytes and the suppression which they mediated appeared to be specific. The mature suppressor cells were radiosensitive. Their precursors were sensitive to large doses of cyclophosphamide. Suppressor-cell activity in the spleen reached a peak after two subcutaneous S. aureus infections and declined thereafter. This decline might be related to the appearance of DH to S. aureus in mice after four or more staphylococcal infections.
在小鼠中,抑制对金黄色葡萄球菌迟发型超敏反应(DH)的细胞是非吞噬性的,能黏附于尼龙毛,具有表面免疫球蛋白,但未检测到Thy 1.抗原。它们可能是B淋巴细胞,且它们介导的抑制作用似乎具有特异性。成熟的抑制细胞对辐射敏感。其前体细胞对大剂量环磷酰胺敏感。在两次皮下注射金黄色葡萄球菌感染后,脾脏中的抑制细胞活性达到峰值,此后下降。这种下降可能与在四次或更多次葡萄球菌感染后小鼠中对金黄色葡萄球菌的DH出现有关。