AKR胸腺抗原及其在白血病和神经组织中的分布。
THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES.
作者信息
REIF A E, ALLEN J M
出版信息
J Exp Med. 1964 Sep 1;120(3):413-33. doi: 10.1084/jem.120.3.413.
A clear-cut serological differentiation between AKR lymphocytes of thymic and non-thymic origin is reported: these two cell types are antigenically distinct. In newborn mice, the AKR thymic antigen was found at a high concentration only in thymus. In adult mice, the antigen was present at a high level in thymus, all nervous tissues tested, and some leukemias. It was present at much lower levels in lymph node lymphocytes, splenic lymphocytes, appendix, lung, and certain other leukemias, which appeared to be of non-thymic origin. The AKR thymic antigen was present at a high level in thymus and nervous tissues of RF mice, but was absent from thymocytes of sixteen other mouse strains. These sixteen strains possessed the C3HeB/Fe thymic antigen. The distribution of this antigen in neonatal and adult tissues of the strains tested was similar to that of the AKR thymic antigen in AKR mice. No exceptions were found. These results were obtained by use of immune cytolysis, and of a new method for the quantitative treatment of data from absorption experiments.
据报道，已明确区分出源于胸腺和非胸腺的AKR淋巴细胞的血清学差异：这两种细胞类型在抗原性上是不同的。在新生小鼠中，AKR胸腺抗原仅在胸腺中以高浓度被发现。在成年小鼠中，该抗原在胸腺、所有检测的神经组织以及一些白血病中高水平存在。在淋巴结淋巴细胞、脾淋巴细胞、阑尾、肺以及某些其他似乎源于非胸腺的白血病中，其水平要低得多。AKR胸腺抗原在RF小鼠的胸腺和神经组织中高水平存在，但在其他16种小鼠品系的胸腺细胞中不存在。这16种品系具有C3HeB/Fe胸腺抗原。该抗原在所检测品系的新生和成年组织中的分布与AKR小鼠中AKR胸腺抗原的分布相似。未发现例外情况。这些结果是通过免疫细胞溶解以及一种用于定量处理吸收实验数据的新方法获得的。
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