暴露时间对避免紫外线辐射诱发白内障的最大可接受剂量的影响。

The effect of exposure time on maximum acceptable dose for avoidance of ultraviolet radiation-induced cataract.

作者信息

Dong Xiuqin, Söderberg Per G, Ayala Marcelo, Löfgren Stefan

机构信息

Department of Clinical Neuroscience, Karolinska Institutet, St. Erik's Eye Hospital, Stockholm, Sweden.

出版信息

Ophthalmic Res. 2005 Jul-Aug;37(4):197-201. doi: 10.1159/000086596. Epub 2005 Jun 29.

DOI:10.1159/000086596

PMID:15990463

Abstract

The effect of exposure time on maximum acceptable dose (MAD) for avoidance of ultraviolet radiation B (UVRB)-induced cataract was investigated. Sprague-Dawley rats were divided into 5 exposure time groups: 7.5, 15, 30, 60, and 120 min. Each exposure time group was divided into 5 dose subgroups: 0, 1, 2, 4, and 8 kJ/m2. The rats were unilaterally exposed to UVR around 300 nm. One week after the exposure, macroscopic structure was recorded and lens forward light scattering was measured. MAD for avoidance of UVRB-induced cataract was estimated based on the dose-response function. MAD for avoidance of UVRB-induced cataract for 7.5, 15, 30, 60, and 120 min exposures was estimated to be 2.0, 1.4, 1.9, 1.8 and 2.2 kJ/m2, respectively. In the exposure time domain 7.5-120 min, MAD for avoidance of UVRB-induced cataract depends on exposure time.

摘要

研究了暴露时间对避免紫外线B（UVRB）诱导性白内障的最大可接受剂量（MAD）的影响。将Sprague-Dawley大鼠分为5个暴露时间组：7.5、15、30、60和120分钟。每个暴露时间组再分为5个剂量亚组：0、1、2、4和8 kJ/m2。大鼠单侧暴露于300 nm左右的紫外线。暴露一周后，记录宏观结构并测量晶状体前向光散射。根据剂量反应函数估算避免UVRB诱导性白内障的MAD。暴露7.5、15、30、60和120分钟时，避免UVRB诱导性白内障的MAD估计分别为2.0、1.4、1.9、1.8和2.2 kJ/m2。在7.5 - 120分钟的暴露时间范围内，避免UVRB诱导性白内障的MAD取决于暴露时间。