Institute of Medical Engineering and Mechatronics, Ulm University of Applied Sciences, 89081 Ulm, Germany.
Medicina (Kaunas). 2021 May 27;57(6):535. doi: 10.3390/medicina57060535.
: Cataract is still the leading cause of blindness. Its development is well researched for UV radiation. Modern light sources like LEDs and displays tend to emit blue light. The effect of blue light on the retina is called blue light hazard and is studied extensively. However, its impact on the lens is not investigated so far. : Investigation of the impact of the blue visible light in porcine lens compared to UVA and UVB radiation. : In this ex-vivo experiment, porcine lenses are irradiated with a dosage of 6 kJ/cm at wavelengths of 311 nm (UVB), 370 nm (UVA), and 460 nm (blue light). Lens transmission measurements before and after irradiation give insight into the impact of the radiation. Furthermore, dark field images are taken from every lens before and after irradiation. Cataract development is illustrated by histogram linearization as well as faults coloring of recorded dark field images. By segmenting the lens in the background's original image, the lens condition before and after irradiation could be compared. : All lenses irradiated with a 6 kJ/cm reveal cataract development for radiation with 311 nm, 370 nm, and 460 nm. Both evaluations reveal that the 460 nm irradiation causes the most cataract. : All investigated irradiation sources cause cataracts in porcine lenses-even blue visible light.
白内障仍然是导致失明的主要原因。人们对紫外线辐射引起的白内障发展进行了深入研究。现代光源，如 LED 和显示器，往往会发出蓝光。蓝光对视网膜的影响被称为蓝光危害，目前已经进行了广泛的研究。然而，到目前为止，其对晶状体的影响尚未得到调查。
调查蓝光可见辐射对猪晶状体的影响，并与 UVA 和 UVB 辐射进行比较。
在这项离体实验中，猪晶状体在波长为 311nm（UVB）、370nm（UVA）和 460nm（蓝光）的条件下，接受了 6kJ/cm 的剂量照射。辐照前后的晶状体透过率测量可深入了解辐射的影响。此外，还从前到后从每只晶状体拍摄暗场图像。白内障的发展通过直方图线性化以及记录的暗场图像的故障着色来表示。通过对背景原始图像中的晶状体进行分割，可以比较辐照前后的晶状体状况。
所有接受 6kJ/cm 剂量照射的晶状体在 311nm、370nm 和 460nm 辐射下均显示出白内障的发展。这两种评估都表明，460nm 的辐照会导致最严重的白内障。
所有被调查的辐照源都会在猪晶状体中引起白内障——甚至是蓝光可见辐射。
