碳-11标记的喜树碱衍生物的放射性合成，作为用于癌症中拓扑异构酶I成像的潜在正电子发射断层扫描示踪剂。
Radiosynthesis of carbon-11-labeled camptothecin derivatives as potential positron emission tomography tracers for imaging of topoisomerase I in cancers.
作者信息
Gao Mingzhang, Miller Kathy D, Sledge George W, Zheng Qi-Huang
机构信息
Department of Radiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
出版信息
Bioorg Med Chem Lett. 2005 Sep 1;15(17):3865-9. doi: 10.1016/j.bmcl.2005.05.108.
Four carbon-11-labeled camptothecin derivatives, 9-[11C]methoxy-20(S)-camptothecin ([11C]5), 10-[11C]methoxy-20(S)-camptothecin ([11C]7), 9-nitro-10-[11C]methoxy-20(S)-camptothecin ([11C]9), and 9-[([11C]trimethylamino)methyl]-10-hydroxy-20(S)-camptothecin ([11C]11), have been synthesized as potential positron emission tomography tracers for imaging of topoisomerase I in cancers.
四种碳-11标记的喜树碱衍生物，9-[11C]甲氧基-20(S)-喜树碱([11C]5)、10-[11C]甲氧基-20(S)-喜树碱([11C]7)、9-硝基-10-[11C]甲氧基-20(S)-喜树碱([11C]9)和9-[([11C]三甲基氨基)甲基]-10-羟基-20(S)-喜树碱([11C]11)，已被合成为潜在的正电子发射断层显像剂，用于癌症中拓扑异构酶I的成像。
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