Yang Na, Tong Xin, Xiang Ye, Zhang Ying, Sun Hui, Wang Da-Cheng
Center for Structural and Molecular Biology, Institute of Biophysics, Chinese Academy of Science, Beijing 100101, People's Republic of China.
Biochim Biophys Acta. 2005 Aug 10;1751(2):209-12. doi: 10.1016/j.bbapap.2005.06.003.
The antitumour lectin from Agrocybe aegerita, named AAL, shows strong inhibition effects on human and mouse tumour cells via apoptosis induction activity. Recombinant AAL (rAAL) has been expressed and purified. Both rAAL and rAAL-lactose complex have been crystallized and their X-ray diffraction data were collected to resolutions of 1.9 A and 1.6 A, respectively. Both crystals belong to space group P2(1) with unit cell parameters a = 53.20 A, b = 66.01 A, c = 57.86 A, beta = 109.38 and a = 53.38 A, b = 66.29 A, c = 58.02 A, beta = 109.03, respectively.
来自高大环柄菇的抗肿瘤凝集素，名为AAL，通过诱导凋亡活性对人和小鼠肿瘤细胞显示出强烈的抑制作用。重组AAL（rAAL）已被表达和纯化。rAAL和rAAL-乳糖复合物均已结晶，并且分别收集了它们的X射线衍射数据，分辨率分别为1.9 Å和1.6 Å。两种晶体都属于空间群P2(1)，晶胞参数分别为a = 53.20 Å，b = 66.01 Å，c = 57.86 Å，β = 109.38以及a = 53.38 Å，b = 66.29 Å，c = 58.02 Å，β = 109.03。
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