丙戊酸和全反式维甲酸用于治疗老年急性髓系白血病患者。
Valproic acid and all-trans retinoic acid for the treatment of elderly patients with acute myeloid leukemia.
作者信息
Raffoux Emmanuel, Chaibi Pascal, Dombret Hervé, Degos Laurent
出版信息
Haematologica. 2005 Jul;90(7):986-8.
PMID:15996941
Abstract
Valproic acid (VPA) has been demonstrated to be able to inhibit histone deacetylase activity and to synergize with all-trans retinoic acid (ATRA) in inducing the differentiation of acute myeloid leukemia (AML) cells. A pilot study of the VPA/ATRA combination was performed in 11 elderly patients with de novo AML (median age, 82 years). Complete marrow response was observed in 3 patients, including 1 complete remission. Two additional patients had hematologic improvement.
摘要
丙戊酸（VPA）已被证明能够抑制组蛋白脱乙酰酶活性，并与全反式维甲酸（ATRA）协同作用诱导急性髓性白血病（AML）细胞分化。对11例初发AML老年患者（中位年龄82岁）进行了VPA/ATRA联合治疗的初步研究。3例患者观察到完全骨髓反应，包括1例完全缓解。另外2例患者有血液学改善。
Zotero 插件