多巴胺转运体基因与酒精中毒的关联。
Association of the dopamine transporter gene with alcoholism.
作者信息
Köhnke Michael D, Batra Anil, Kolb Werner, Köhnke Annette M, Lutz Ulrich, Schick Sandra, Gaertner Ines
机构信息
University Hospital of Psychiatry, Osianderstrasse 24, 72076 Tübingen, Germany.
出版信息
Alcohol Alcohol. 2005 Sep-Oct;40(5):339-42. doi: 10.1093/alcalc/agh179. Epub 2005 Jul 4.
AIMS
It was investigated whether the allele A9 of the dopamine transporter gene (DAT1; SLC6A3) is associated with alcoholism, delirium tremens (DT), alcohol withdrawal seizures (AWS), or the daily alcohol intake.
METHODS
A group of 102 healthy subjects and 216 alcoholics, including 97 patients with a history of mild withdrawal symptoms, 65 with a history of AWS and 83 with a history of DT were genotyped and personal data were achieved for statistical evaluation in a case-control design.
RESULTS
The frequency of individuals carrying the allele A9 [f(A9+)] was significantly higher (P = 0.01) in the group of alcoholics [f(A9+) = 0.48] compared with healthy controls [f(A9+) = 0.32]. There was no significant association of the allele A9 with severe withdrawal symptoms or the daily amount of alcohol consumed.
CONCLUSIONS
Our results reveal that the allele A9 is strongly associated with alcoholism but not with withdrawal symptoms or daily alcohol intake.
目的
研究多巴胺转运体基因（DAT1；SLC6A3）的A9等位基因是否与酒精中毒、震颤谵妄（DT）、酒精戒断性癫痫发作（AWS）或每日酒精摄入量有关。
方法
对102名健康受试者和216名酗酒者进行基因分型，其中包括97名有轻度戒断症状史的患者、65名有AWS病史的患者和83名有DT病史的患者，并获取个人数据，采用病例对照设计进行统计评估。
结果
与健康对照组[f(A9+) = 0.32]相比，酗酒者组[f(A9+) = 0.48]中携带A9等位基因的个体频率显著更高（P = 0.01）。A9等位基因与严重戒断症状或每日酒精摄入量之间无显著关联。
结论
我们的结果表明，A9等位基因与酒精中毒密切相关，但与戒断症状或每日酒精摄入量无关。
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