Ballard Cortney L, Wood Ruth I
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Behav Neurosci. 2005 Jun;119(3):752-8. doi: 10.1037/0735-7044.119.3.752.
Previous studies by the authors have shown voluntary intracerebroventricular (icv) testosterone self-administration in hamsters (Mesocricetus auratus). Here, the authors compared icv self-administration of 4 anabolic steroids (drostanolone, nandrolone, oxymetholone, and stanozolol) at 0.1, 1.0, and 2.0 microg/microl, each for 8 days. Males (n=8/group) showed the highest levels of operant behavior for injectable steroids (drostanolone, nandrolone) compared with orally active androgens (oxymetholone, stanozolol). For nandrolone, responses on the active and inactive nose-pokes averaged 22.3 +/- 4.6/4 hr and 10.7 +/- 2.0/4 hr, respectively. Responding for drostanolone was similar. Males self-administering oxymetholone or stanozolol did not prefer the active nose-poke. These data demonstrate that injectable androgens are more reinforcing than oral steroids.
作者之前的研究已表明仓鼠（金黄仓鼠）能够自主进行脑室内（icv）注射睾酮。在此，作者比较了4种合成代谢类固醇（羟甲雄酮、诺龙、羟甲烯龙和司坦唑醇）在0.1、1.0和2.0微克/微升剂量下的脑室内自我给药情况，每种剂量给药8天。与口服活性雄激素（羟甲烯龙、司坦唑醇）相比，雄性（每组n = 8）对可注射类固醇（羟甲雄酮、诺龙）表现出最高水平的操作性行为。对于诺龙，主动和非主动鼻触的反应平均分别为22.3±4.6/4小时和10.7±2.0/4小时。羟甲雄酮的反应情况类似。自我给药羟甲烯龙或司坦唑醇的雄性并不偏好主动鼻触。这些数据表明，可注射雄激素比口服类固醇更具强化作用。
