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药物供应减少对药物依赖治疗需求及治疗依从性的影响。

The impact of a reduction in drug supply on demand for and compliance with treatment for drug dependence.

作者信息

Degenhardt Louisa, Conroy Elizabeth, Day Carolyn, Gilmour Stuart, Hall Wayne

机构信息

National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW 2052, Australia.

出版信息

Drug Alcohol Depend. 2005 Aug 1;79(2):129-35. doi: 10.1016/j.drugalcdep.2005.01.018. Epub 2005 Mar 2.

Abstract

BACKGROUND

In early 2001, Australia experienced a sudden, dramatic and sustained decrease in heroin availability that was accompanied by sharp increases in price and decreases in street level purity--the so-called "heroin shortage". These unprecedented changes occurred in a context of widespread treatment availability, which made it possible for the first time to examine the impact of a sharp reduction in heroin supply in New South Wales (NSW) on entry to and adherence with treatment for heroin dependence. Given the evidence of drug substitution by some users, the current paper also examines the effects of the shortage on entry to treatment for other forms of drug dependence.

METHODS

Interrupted time-series analysis of the number of persons entering opioid pharmacotherapy and other treatment modalities in NSW for heroin dependence and for the treatment for other types of drug dependence.

FINDINGS

The heroin shortage was associated with a reduction in the number of younger persons entering opioid pharmacotherapy. There was a dramatic decrease in the number of persons entering heroin withdrawal or "assessment only" treatment episodes. There appear to have been small improvements in adherence to and retention in heroin treatment after the reduction in heroin supply. Relatively small increases were observed in numbers being treated for cocaine dependence.

CONCLUSIONS

In the context of good treatment provision, a reduction in heroin supply appeared to produce modest improvements in intermediate outcomes. Supply and demand reduction measures, when both are implemented successfully, may be complementary.

摘要

背景

2001年初,澳大利亚海洛因供应突然、急剧且持续减少,同时价格大幅上涨,街头纯度下降,即所谓的“海洛因短缺”。这些前所未有的变化发生在广泛提供治疗的背景下,这使得首次能够研究新南威尔士州(NSW)海洛因供应急剧减少对海洛因依赖治疗的进入和坚持治疗的影响。鉴于一些使用者药物替代的证据,本文还研究了短缺对其他形式药物依赖治疗进入的影响。

方法

对新南威尔士州进入阿片类药物治疗及其他治疗方式治疗海洛因依赖和其他类型药物依赖的人数进行中断时间序列分析。

结果

海洛因短缺与进入阿片类药物治疗的年轻人数量减少有关。进入海洛因脱毒或“仅评估”治疗阶段的人数急剧下降。海洛因供应减少后,海洛因治疗的坚持率和留存率似乎有小幅改善。接受可卡因依赖治疗的人数相对小幅增加。

结论

在提供良好治疗的背景下,海洛因供应减少似乎在中间结果方面产生了适度改善。成功实施供应减少和需求减少措施可能具有互补性。

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