高剂量甲基强的松龙可诱导多发性硬化症患者粒细胞上的FcγRI。

High dose methylprednisolone induces FcgammaRI on granulocytes in MS-patients.

作者信息

Torkildsen O, Vedeler C A, Ulvestad E, Aarseth J H, Nyland H I, Myhr K-M

机构信息

The Multiple Sclerosis National Competence Centre, Department of Clinical Medicine, Section for Neurology, Haukeland University Hospital, University of Bergen, N-5021 Bergen, Norway.

出版信息

J Neuroimmunol. 2005 Oct;167(1-2):138-42. doi: 10.1016/j.jneuroim.2005.06.009.

DOI:10.1016/j.jneuroim.2005.06.009

PMID:16002152

Abstract

Immune complexes impinge on receptors for the Fc domain of IgG (FcgammaR) and may thus influence the disease course in multiple sclerosis (MS). We analyzed FcgammaR distribution on monocytes and granulocytes in twenty relapsing-remitting MS patients at baseline, immediately after a five day course of high dose intravenous methylprednisolone (IVMP) treatment and after two months. After a five day course of IVMP the proportion of granulocytes with FcgammaRI was increased, P=0,002. There was no change in FcgammaRII and FcgammaRIII expression. The effect of IVMP on FcgammaRI expression could be important for the clearance of immune complexes in MS.

摘要

免疫复合物作用于IgG的Fc结构域受体（FcγR），因此可能影响多发性硬化症（MS）的病程。我们分析了20例复发缓解型MS患者在基线、接受为期5天的大剂量静脉注射甲基强的松龙（IVMP）治疗后即刻以及2个月后的单核细胞和粒细胞上FcγR的分布情况。在接受为期5天的IVMP治疗后，具有FcγRI的粒细胞比例增加，P = 0.002。FcγRII和FcγRIII的表达没有变化。IVMP对FcγRI表达的影响可能对MS中免疫复合物的清除具有重要意义。