Wynn Melissa, Dalovisio Joseph R, Tice Alan D, Jiang Xiaozhang
Ochsner Clinic Foundation, Section on Infectious Diseases, New Orleans, LA, USA.
South Med J. 2005 Jun;98(6):590-5. doi: 10.1097/01.SMJ.0000145300.28736.BB.
As increasing numbers of patients are being treated with outpatient parenteral antimicrobial therapy (OPAT), it becomes ever more important to ascertain the risks and benefits of such treatment for patients.
We conducted a retrospective analysis of 1,515 patients with methicillin-sensitive Staphylococcus aureus infections who were treated with outpatient parenteral antimicrobial monotherapy. All patients were included in the adverse drug reaction analysis; 1,252 were evaluable for purposes of evaluating treatment efficacy.
The six antibiotics most frequently used in this study (ceftriaxone, cefazolin, vancomycin, oxacillin, nafcillin, and clindamycin) appeared to be equivalent in achieving the desired efficacy outcome.
Vancomycin was associated with a significantly greater number of side effects than was ceftriaxone, cefazolin, or oxacillin, and nafcillin was associated with a significantly greater number of adverse events than ceftriaxone.
随着越来越多的患者接受门诊胃肠外抗菌治疗（OPAT），确定此类治疗对患者的风险和益处变得愈发重要。
我们对1515例接受门诊胃肠外抗菌单药治疗的甲氧西林敏感金黄色葡萄球菌感染患者进行了回顾性分析。所有患者均纳入药物不良反应分析；1252例可用于评估治疗效果。
本研究中最常用的六种抗生素（头孢曲松、头孢唑林、万古霉素、苯唑西林、萘夫西林和克林霉素）在实现预期疗效方面似乎相当。
与头孢曲松、头孢唑林或苯唑西林相比，万古霉素的副作用明显更多，且与头孢曲松相比，萘夫西林的不良事件明显更多。
