Gottfried Kristy, Quinn Robbie, Jones Tim
Tennessee Department of Health, Communicable and Environmental Disease Service, Nashville, TN 37247-3901, USA.
South Med J. 2005 Jun;98(6):603-6. doi: 10.1097/01.SMJ.0000155633.43244.AC.
The objective of this study was to investigate long-term outcomes after West Nile virus infection.
We reviewed the medical records of persons reported with West Nile virus in Tennessee in 2002 and interviewed cases 1 year after acute illness.
In 2002, 56 cases of West Nile virus were reported in Tennessee; 48 (84%) had meningitis or encephalitis. Of those, 9 (19%) died during acute infection and 12 (25%) died within 6 months of illness onset. Patients with West Nile virus neurologic illness spent a median of 10 days in the hospital and were unable to resume normal activities for a median of 25 days. One year later, 12 of 22 (55%) persons reported that they were not fully recovered, with symptoms including fatigue, weakness, difficulty ambulating, and memory problems.
West Nile virus infection leads to high rates of mortality and substantial persistent morbidity. Prevention efforts should be targeted to populations at highest risk of severe sequelae.
本研究的目的是调查西尼罗河病毒感染后的长期结局。
我们回顾了2002年田纳西州报告的感染西尼罗河病毒的人员的病历，并在急性疾病发生1年后对病例进行了访谈。
2002年，田纳西州报告了56例西尼罗河病毒病例；48例（84%）患有脑膜炎或脑炎。其中，9例（19%）在急性感染期间死亡，12例（25%）在发病后6个月内死亡。感染西尼罗河病毒的神经系统疾病患者住院时间中位数为10天，无法恢复正常活动的时间中位数为25天。1年后，22例中的12例（55%）报告称他们尚未完全康复，症状包括疲劳、虚弱、行走困难和记忆问题。
西尼罗河病毒感染导致高死亡率和大量持续的发病率。预防措施应针对发生严重后遗症风险最高的人群。
