分离的Pelle死亡结构域的溶液结构
Solution structure of the isolated Pelle death domain.
作者信息
Moncrieffe Martin C, Stott Katherine M, Gay Nicholas J
机构信息
Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.
出版信息
FEBS Lett. 2005 Jul 18;579(18):3920-6. doi: 10.1016/j.febslet.2005.06.009.
The interaction between the death domains (DDs) of Tube and the protein kinase Pelle is an important component of the Toll pathway. Published crystallographic data suggests that the Pelle-Tube DD interface is plastic and implies that in addition to the two predominant Pelle-Tube interfaces, a third interaction is possible. We present the NMR solution structure of the isolated death domain of Pelle and a study of the interaction between the DDs of Pelle and Tube. Our data suggests the solution structure of the isolated Pelle DD is similar to that of Pelle DD in complex with Tube. Additionally, they suggest that the plasticity observed in the crystal structure may not be relevant in the functioning death domain complex.
Tube的死亡结构域（DDs）与蛋白激酶Pelle之间的相互作用是Toll信号通路的一个重要组成部分。已发表的晶体学数据表明，Pelle-Tube DD界面具有可塑性，这意味着除了两种主要的Pelle-Tube界面外，第三种相互作用也是可能的。我们展示了分离出的Pelle死亡结构域的核磁共振溶液结构，并对Pelle和Tube的DDs之间的相互作用进行了研究。我们的数据表明，分离出的Pelle DD的溶液结构与与Tube结合的Pelle DD的结构相似。此外，数据还表明，在晶体结构中观察到的可塑性在功能性死亡结构域复合物中可能并不相关。
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