Cuadrado-Tejedor Mar, Sesma M Teresa, Giménez-Amaya José Manuel, Ortiz Lourdes
Area de Neurociencias, Centro de Investigación Médica Aplicada, Facultad de Medicina, Universidad de Navarra, Avda de Pio XII 55, 31080 Pamplona, Spain.
Neurobiol Dis. 2005 Dec;20(3):666-72. doi: 10.1016/j.nbd.2005.05.014. Epub 2005 Jul 6.
Parkinson's disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra and a marked reduction of dopamine (DA) levels in the striatum. Binding to its specific receptors, DA switches on a complex program of intracellular signaling that regulates gene expression. We evaluated the changes in striatal gene expression in a mouse model of Parkinson's disease, using differential display analysis. The mRNA for the cytoskeleton family proteins, radixin, cofilin and centractin/ARP-1, was abnormally expressed in the striatum of these MPTP-treated mice. Moreover, we also found that radixin mRNA and its protein levels are under DA control through specific D1-dopaminergic receptors in a dose- and time-dependent manner in the GT1-7 neural cell line. These findings suggest a role for DA for regulation of cytoskeletal proteins involved in the integrity and function of synapsis.
