Pisoni Giuliano, Quasso Antonio, Moroni Paolo
Department of Animal Pathology, Hygiene and Veterinary Public Health, University of Milano, via Celoria 10, 20133 Milano, Italy.
Virology. 2005 Sep 1;339(2):147-52. doi: 10.1016/j.virol.2005.06.013.
Small-ruminant lentiviruses (SRLV), consisting of the caprine arthritis-encephalitis virus (CAEV) and the maedi-visna virus (MVV), cause chronic multisystemic infections in goats and sheep. The SRLV subtype B1, characterized by the prototypic strain CAEV-CO, has a worldwide distribution and, remarkably, has been isolated exclusively from goats, suggesting potential host specificity. To test this hypothesis, SRLV pol sequences were obtained by PCR amplification from blood samples of seropositive dairy goats and sheep living in mixed flocks. Phylogenetic analysis of these sequences demonstrates that SRLV subtype B1 does cross the species barrier under field conditions through direct contact between adult animals. This implies that SRLV control programs targeting only sheep or goats can no longer be proposed (based on a putative species specificity of the SRLV subtype B1).
小反刍兽慢病毒（SRLV）由山羊关节炎-脑炎病毒（CAEV）和梅迪-维斯纳病毒（MVV）组成，可在山羊和绵羊中引起慢性多系统感染。以原型毒株CAEV-CO为特征的SRLV B1亚型在全球范围内分布，并且值得注意的是，仅从山羊中分离得到，这表明其具有潜在的宿主特异性。为了验证这一假设，通过PCR扩增从生活在混合羊群中的血清阳性奶山羊和绵羊的血液样本中获取SRLV pol序列。对这些序列的系统发育分析表明，SRLV B1亚型在野外条件下可通过成年动物之间的直接接触跨越物种屏障。这意味着不能再提出仅针对绵羊或山羊的SRLV防控计划（基于SRLV B1亚型假定的物种特异性）。
