II期子宫内膜癌：对于淋巴结阴性肿瘤，将术后放疗局限于阴道穹窿。
Stage II endometrial carcinoma: limiting post-operative radiotherapy to the vaginal vault in node-negative tumors.
作者信息
Rittenberg Paula V C, Lotocki Robert J, Heywood Mark S, Krepart Garry V
机构信息
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Dalhousie University, Dickson Building, 5820 University Avenue, Halifax, Nova Scotia, Canada B3H 1V7.
出版信息
Gynecol Oncol. 2005 Sep;98(3):434-8. doi: 10.1016/j.ygyno.2005.04.030.
OBJECTIVE
To evaluate the outcomes of patients with node-negative stage II endometrial cancer who received vault brachytherapy without external beam pelvic radiotherapy (EBRT).
METHODS
A retrospective review of all stage II endometrioid type endometrial cancer patients referred to Cancer Care Manitoba was undertaken between October 1995 and March 2001. Forty-nine patients were identified with disease confined to the uterus, but not all patients received extended surgical staging (ESS) with pelvic lymphadenectomy. These patients were evaluated for recurrence and morbidity data.
RESULTS
Twenty node-negative stage II cancers were identified. Three were treated without adjuvant treatment, 12 received vault brachytherapy and 5 received more conventional treatment with EBRT and vault brachytherapy. No recurrences or deaths occurred in these patients. Mean follow-up was 40 months. No surgical complications were encountered in this group and no morbidity from radiotherapy was observed.
CONCLUSIONS
Limiting adjuvant treatment to vault brachytherapy for node-negative stage II endometrial cancer results in less morbidity and excellent survival and is worthy of further investigation.
目的
评估未接受盆腔外照射放疗（EBRT）而接受阴道近距离放疗的II期子宫内膜癌淋巴结阴性患者的治疗结果。
方法
对1995年10月至2001年3月间转诊至曼尼托巴癌症护理中心的所有II期子宫内膜样型子宫内膜癌患者进行回顾性研究。确定了49例疾病局限于子宫的患者，但并非所有患者都接受了盆腔淋巴结清扫的扩大手术分期（ESS）。对这些患者的复发和发病数据进行了评估。
结果
确定了20例II期淋巴结阴性癌症。3例未接受辅助治疗，12例接受了阴道近距离放疗，5例接受了更传统的EBRT加阴道近距离放疗。这些患者均未出现复发或死亡。平均随访时间为40个月。该组未出现手术并发症，也未观察到放疗引起的发病情况。
结论
对于II期子宫内膜癌淋巴结阴性患者，将辅助治疗局限于阴道近距离放疗可降低发病率并获得良好的生存率，值得进一步研究。
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