下丘脑腹内侧核的产后发育：神经元与突触
Postnatal development of the hypothalamic ventromedial nucleus: neurons and synapses.
作者信息
Pozzo Miller L D, Aoki A
机构信息
Centro de Microscopia Electronica, Universidad Nacional de Cordoba, Argentina.
出版信息
Cell Mol Neurobiol. 1992 Apr;12(2):121-9. doi: 10.1007/BF00713366.
Abstract
- In this report the postnatal differentiation of the hypothalamic ventromedial nucleus (VMN) was studied. The main maturational changes detected at the fine structural level occurred between 10 and 20 days of postnatal life. 2. In 5-day-old rats the majority of neurons was undifferentiated, with rudimentary cytoplasmic organelles. Dendritic profiles presented an empty appearance due to an electron-lucent matrix and scarce content of organelles. 3. At 10 days there was a significant proliferation of cytoplasmic organelles in the perikaryon, mainly of those involved in protein biosynthesis as the rough endoplasmic reticulum (RER) and the Golgi complex. 4. After 20 days of age the VMN neurons acquired the cytological appearance of adult neurons, with well-organized RER, Golgi complexes, and pleomorphic mitochondria. Concurrent with these changes, there was a marked development of other organelles in the neuropil, which was accompanied by an increase in synaptic density and differentiation of their subsynaptic structures.
摘要
- 在本报告中，对下丘脑腹内侧核（VMN）的产后分化进行了研究。在精细结构水平上检测到的主要成熟变化发生在出生后10至20天之间。2. 在5日龄大鼠中，大多数神经元未分化，细胞质细胞器发育不全。由于电子透明基质和细胞器含量稀少，树突轮廓呈现出空泡状外观。3. 在10日龄时，核周质中的细胞质细胞器显著增殖，主要是参与蛋白质生物合成的细胞器，如粗面内质网（RER）和高尔基体。4. 20日龄后，VMN神经元获得了成年神经元的细胞学外观，具有组织良好的RER、高尔基体和多形性线粒体。伴随着这些变化，神经毡中的其他细胞器也有显著发育，同时突触密度增加，突触下结构分化。
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