Holst Manuela, Eswaran Hari, Lowery Curtis, Murphy Pamela, Norton Jonathan, Preissl Hubert
Department of Obstetrics and Gynecology, SARA Research Center, University of Arkansas for Medical Sciences, 4301 W. Markham St., Slot 518, Little Rock, AR 72205, USA.
Clin Neurophysiol. 2005 Aug;116(8):1949-55. doi: 10.1016/j.clinph.2005.04.008.
To investigate the maturation of the auditory cortex by non-invasive recording of auditory evoked magnetic fields in human fetuses and newborns with the relatively novel and completely non-invasive technology of MEG.
Serial recordings were performed every 2 weeks on 18 fetuses beginning from week 27 of gestational age until term with a follow-up recording on the newborn. Auditory stimulation consisted of tone bursts in an oddball design with standard tones and deviant tones.
In 52 of 63 fetal and in all of the neonatal recordings an auditory evoked magnetic field was obtained. A decrease in latency with increasing age of the subjects was observed in the combined analysis of fetuses and neonates.
With advanced study using MEG, 83% of the measurements showed auditory evoked fields in fetuses that correspond with existing literature in electrophysiology in the past. These findings indicate that MEG is a technique that can be used to investigate maturation of the auditory cortex based on auditory evoked fields in fetuses and neonates.
Maturational changes have been examined in the past. With the use of this novel technique, applied to a serial study, it is possible to trace the development of auditory responses in utero and newborns.
运用相对新颖且完全无创的脑磁图（MEG）技术，通过对人类胎儿和新生儿听觉诱发磁场进行无创记录，来研究听觉皮层的成熟情况。
从孕27周开始，每2周对18例胎儿进行系列记录直至足月，并在新生儿期进行随访记录。听觉刺激采用包含标准音和偏差音的奇偶数设计的短纯音。
在63次胎儿记录中的52次以及所有新生儿记录中均获得了听觉诱发磁场。在对胎儿和新生儿的综合分析中，观察到随着受试者年龄增长潜伏期缩短。
通过使用MEG进行的深入研究，83%的测量显示胎儿的听觉诱发场与过去电生理学的现有文献相符。这些发现表明，MEG是一种可用于基于胎儿和新生儿听觉诱发场来研究听觉皮层成熟情况的技术。
过去已经研究过成熟变化。运用这种应用于系列研究的新技术，有可能追踪子宫内和新生儿听觉反应的发育情况。
