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[真性红细胞增多症作为短暂性全面性遗忘症的一个现成因素]

[Polycythaemia as a ready factor of transitory global amnesia].

作者信息

Toledo M, Pujadas F, Purroy F, Alvarez-Sabin J

机构信息

Servicio de Neurología, Hospital Vall d'Hebron, Barcelona.

出版信息

Neurologia. 2005 Jul-Aug;20(6):317-20.

Abstract

Transitory global amnesia (TGA) is an upheaval where the patient has anterograde memory lost of abrupt beginning and an inferior duration to 24 h, that has been related to ischaemic, epileptogenic and migranous ethiology. On the other hand polycythaemia is classified like a prothrombotic disorder that can produce manifold manifestations in the central nervous system, from strokes to psychiatric disturbances of anxious type, and all related to the secondary cerebral hipoperfusión due to hyperviscosity. Two patients, who had a previous diagnostic of polycythaemia suffered an episode of TGA, in addition in one of the two cases a cerebellar hemangioblastoma was found. There are numerous cases reported of brain tumors and other CNS findings diagnosed as a result of an episode of TGA, nevertheless on has not described to the relation between polycythaemia and the TGA. In the TGA a hypoperfusion of the temporal brain hemisphere has been documented and this can be a leading mechanism, so we propose that polycythaemia could ready to suffer a TGA.

摘要

短暂性全面性遗忘症(TGA)是一种突发状况,患者会出现顺行性记忆丧失,起病突然,持续时间小于24小时,其病因与缺血、癫痫发作和偏头痛有关。另一方面,红细胞增多症被归类为一种血栓前状态疾病,可在中枢神经系统产生多种表现,从中风到焦虑型精神障碍,所有这些都与高粘滞血症导致的继发性脑灌注不足有关。两名曾被诊断为红细胞增多症的患者发生了TGA发作,此外,在这两例中的一例还发现了小脑成血管细胞瘤。有许多病例报告称,因TGA发作而诊断出脑肿瘤和其他中枢神经系统病变,然而,尚未有人描述红细胞增多症与TGA之间的关系。在TGA中,已证实颞叶脑半球存在灌注不足,这可能是主要机制,因此我们认为红细胞增多症可能易患TGA。

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