Wang Ning-Yu, Su Jin-Fei, Dong Hui-Qing, Jia Jian-Ping, Han De-Min
Department of Otorhinolaryngology Head and Neck Surgery, Chaoyang Hospital, Capital University of Medical Sciences, Beijing 100020, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2005 Apr;40(4):279-82.
To study the relationship between the degrees of peripheral auditory dysfunction and clinical dementia rating (CDR) in the patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD).
Pure-tone thresholds (PT), word recognition scores (WRS), acoustic immittance and auditory brain-stem responses (ABR) were done to evaluate the auditory function in 24 cases of the patients with MCI and in 31 cases of the patients with AD and in 50 subjects of the control group. Clinical dementia rating (CDR) questionnaire was used to define the dementia degree of the subjects.
Twenty-four MCI patients and 31 AD patients were selected, with average age of 72.0 +/- 6. 5 and 73.1+/-7. 5 of whom 70.8% and 67.7% were female separately. There was no significant difference in PTT and WRS between the MCI and AD groups (P > 0.05). In order to ascertain the relationship between hearing level and degree of dementia, all subjects were divided into 4 groups according their hearing loss (PTA <25 dB:0, 25-30 dB:1, 31-35 dB:2, >35 dB:3) to compare their CDR scores (the control:0, MCI:0. 5, mild AD:1). The more the CDR scores have, the more hearing impairment after controlling the confounder factors (Kendalls tau b = - 0.285, P = 0.018). No significant difference was found between the two groups in audiometry reliability, acoustic immittance and ABR (P > 0.05).
The positive relationship was founded the peripheral hearing impairment and the score of CDR questionnaire in less than 0.5 score of CDR groups and mild AD patients.
研究轻度认知障碍（MCI）和阿尔茨海默病（AD）患者外周听觉功能障碍程度与临床痴呆评定量表（CDR）之间的关系。
对24例MCI患者、31例AD患者和50例对照组受试者进行纯音听阈（PT）、言语识别得分（WRS）、声导抗和听觉脑干反应（ABR）检查以评估听觉功能。采用临床痴呆评定量表（CDR）问卷确定受试者的痴呆程度。
选取24例MCI患者和31例AD患者，平均年龄分别为72.0±6.5岁和73.1±7.5岁，其中女性分别占70.8%和67.7%。MCI组和AD组之间的PTT和WRS无显著差异（P>0.05）。为确定听力水平与痴呆程度之间的关系，根据听力损失情况将所有受试者分为4组（PTA<25dB：0组，25 - 30dB：1组，31 - 35dB：2组，>35dB：3组），比较他们的CDR得分（对照组：0分，MCI：0.5分，轻度AD：1分）。在控制混杂因素后，CDR得分越高，听力损害越严重（肯德尔tau b系数=-0.285，P = 0.018）。两组在听力测定可靠性、声导抗和ABR方面无显著差异（P>0.05）。
在CDR评分低于0.5分的组和轻度AD患者中，外周听力损害与CDR问卷得分呈正相关。
