禁食或糖尿病大鼠中脂肪酸的α-氧化作用

Alpha-oxidation of fatty acids in fasted or diabetic rats.

作者信息

Takahashi T, Takahashi H, Takeda H, Shichiri M

机构信息

Department of Metabolic Medicine, Kumamoto University Medical School, Japan.

出版信息

Diabetes Res Clin Pract. 1992 May;16(2):103-8. doi: 10.1016/0168-8227(92)90080-b.

DOI:10.1016/0168-8227(92)90080-b

PMID:1600847

Abstract

Induction of alpha-oxidation, a possible gluconeogenic process, which should produce odd-chain fatty acids from even-chain fatty acids, was studied in rats fasted or made diabetic with streptozotocin. When a omega-phenylated even-chain fatty acid, phenylbutyric acid (1.2 mmol/kg), was administered to rats under these conditions, a significant increase in the urinary excretion of benzoic acid, the metabolic end-product of omega-phenylated odd-chain fatty acids, was observed in fasted (3.54 +/- 0.46 mumol/day) and diabetic (6.73 +/- 2.10) rats (control, 0.58 +/- 0.43; P less than 0.001). Phenylated longer chain fatty acids, phenylhexanoic and phenyldecanoic acid, did not produce significantly more benzoic acid than did phenylbutyric acid. Although the rate of alpha-oxidation was very low compared to that of beta-oxidation, these results suggested that alpha-oxidation of fatty acids was induced under fasting or diabetic conditions, and that alpha-oxidation might take place at the butyric acid stage.

摘要

对禁食或用链脲佐菌素诱导糖尿病的大鼠中α-氧化（一种可能的糖异生过程，该过程应由偶数链脂肪酸产生奇数链脂肪酸）进行了研究。在这些条件下，当向大鼠给予ω-苯基化的偶数链脂肪酸苯丁酸（1.2 mmol/kg）时，在禁食大鼠（3.54±0.46 μmol/天）和糖尿病大鼠（6.73±2.10）中观察到ω-苯基化奇数链脂肪酸的代谢终产物苯甲酸的尿排泄量显著增加（对照组为0.58±0.43；P<0.001）。苯基化的长链脂肪酸苯己酸和苯癸酸产生的苯甲酸并不比苯丁酸显著更多。尽管与β-氧化相比，α-氧化的速率非常低，但这些结果表明，在禁食或糖尿病条件下脂肪酸的α-氧化被诱导，并且α-氧化可能在丁酸阶段发生。