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外用甲基氨基乙酰丙酸光动力疗法治疗Queyrat增殖性红斑

Erythroplasia of Queyrat treated with topical methyl aminolevulinate photodynamic therapy.

作者信息

Lee Michael R, Ryman William

机构信息

Department of Dermatology, Royal North Shore Hospital, St Leonards, New South Wales, Australia.

出版信息

Australas J Dermatol. 2005 Aug;46(3):196-8. doi: 10.1111/j.1440-0960.2005.00179.x.

DOI:10.1111/j.1440-0960.2005.00179.x
PMID:16008656
Abstract

An 82-year-old man presented with invasive squamous cell carcinoma of the glans penis arising in erythroplasia of Queyrat. He underwent Mohs' micrographic surgery for the invasive carcinoma. Seven weeks later, the residual erythroplasia of Queyrat was treated using photodynamic therapy. Methyl aminolevulinate cream was applied to the glans of the penis under occlusion for 3 hours and then, after local anaesthesia, irradiated with a 630-nm red-light-emitting diode lamp at a dose of 37 J/cm(2) for 8 min. The patient experienced some mild swelling, redness and pain, which subsided over the following 5 days. Eighteen weeks after photodynamic therapy, there had been no recurrence of the lesion, when the patient died from an unrelated cause.

摘要

一名82岁男性,患有起源于凯腊增殖性红斑的阴茎头浸润性鳞状细胞癌。他接受了针对浸润性癌的莫氏显微外科手术。七周后,采用光动力疗法治疗残留的凯腊增殖性红斑。将氨基酮戊酸甲酯乳膏封包涂抹于阴茎头3小时,然后在局部麻醉后,用波长630 nm的红光发光二极管灯以37 J/cm²的剂量照射8分钟。患者出现了一些轻度肿胀、发红和疼痛,在接下来的5天内消退。光动力治疗18周后,病变未复发,随后患者死于 unrelated cause(此处原文有误,推测可能是“无关原因”)。

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Lasers Med Sci. 2016 Dec;31(9):1971-1976. doi: 10.1007/s10103-016-2005-9. Epub 2016 Jun 21.
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Expert Rev Anticancer Ther. 2010 Nov;10(11):1797-809. doi: 10.1586/era.10.154.
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