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前列腺癌筛查:对象是谁以及筛查频率如何?

Screening for prostate cancer: who and how often?

作者信息

Schwartz Kendra, Deschere Bruce, Xu Jinping

机构信息

Department of Family Medicine, Wayne State University School of Medicine, 101 E. Alexandrine, Detroit, MI 48201, USA.

出版信息

J Fam Pract. 2005 Jul;54(7):586-96.

PMID:16009085
Abstract

Engage patients in shared decision making by discussing the benefits and risks of prostate cancer screening. Patients who review educational pamphlets before an office visit engage more fully in the decision-making process. If performing prostate cancer screening, limit to men with greater than 10 years life expectancy. Because the lead time of a diagnosis based on PSA screening is estimated to be 5 to 7 years, PSA screening every other year is unlikely to cause a loss of sensitivity. Men with tumors with a Gleason score less than 5 are the best candidates for "watchful waiting," having a favorable 20-year survival.

摘要

通过讨论前列腺癌筛查的益处和风险,让患者参与共同决策。在门诊就诊前阅读教育手册的患者能更充分地参与决策过程。如果进行前列腺癌筛查,仅限于预期寿命超过10年的男性。由于基于PSA筛查的诊断提前期估计为5至7年,因此每隔一年进行PSA筛查不太可能导致敏感性降低。Gleason评分小于5的肿瘤男性是“观察等待”的最佳人选,其20年生存率良好。

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