Ritter Robert H, Cryar Anthony K, Hermans Michael R
Division of Urology, Scott and White Memorial Hospital and Clinic, Scott, Sherwood & Brindley Foundation, The Texas A&M University System Health Science Center College of Medicine, Temple, Texas, USA.
Fertil Steril. 2005 Jul;84(1):217. doi: 10.1016/j.fertnstert.2005.01.125.
To report a case of androstenedione (A)-induced impotence and severe oligospermia.
Case report.
Multispecialty tertiary referral center.
PATIENT(S): A 29-year-old married male recreational bodybuilder using the legal dietary supplement A in an attempt to enhance athletic performance.
INTERVENTION(S): Immediate cessation of oral A, Depo-T regimen with a taper, administered during 3 months, to alleviate loss of libido and impotence.
MAIN OUTCOME MEASURE(S): Resolution of symptoms and normalization of semen parameters.
RESULT(S): Resolution of symptoms and normalization of semen parameters at 6 months, and successful intrauterine pregnancy achieved 1 year after initial presentation.
CONCLUSION(S): Oral A has a previously unrecognized side effect, which is the potential to suppress the hypothalamic pituitary gonadal axis.
报告一例因雄烯二酮（A）导致的阳痿和严重少精子症病例。
病例报告。
多专科三级转诊中心。
一名29岁已婚男性业余健美运动员，使用合法的膳食补充剂A以提高运动表现。
立即停用口服A，采用逐渐减量的长效睾酮（Depo-T）方案，在3个月内给药，以缓解性欲减退和阳痿。
症状缓解和精液参数正常化。
6个月时症状缓解，精液参数正常化，初次就诊1年后成功宫内妊娠。
口服A有一个此前未被认识到的副作用，即有可能抑制下丘脑 - 垂体 - 性腺轴。
