Zalewska-Kaszubska Jadwiga, Cwiek Wojciech, Dyr Wanda, Czarnecka Elzbieta
Department of Pharmacodynamics, Medical University of Łódź, Muszyńskiego 1, PL 90-151 Łódź, Poland.
Neurosci Lett. 2005 Nov 4;388(1):45-8. doi: 10.1016/j.neulet.2005.06.032.
The aim of this study was to evaluate the beta-endorphin (beta-endorphin) plasma level in Warsaw Low Preferring (WLP) and Warsaw high-preferring (WHP) rats after repeated administration of acamprosate, one of most effective drug in the treatment of alcoholism. Treatment with acamprosate in dose 200mg/kg, p.o. for 10 days induced an increase in plasma beta-endorphin levels. A single injection of ethanol also results in the increase of beta-endorphin level. Moreover, it was found that single injection of ethanol to WHP rats resulted in lower increase of plasma beta-endorphin content in rats earlier treated with acamprosate. In WLP rats, repeated acamprosate treatment prevents the ethanol-induced increase in plasma beta-endorphin level. It may be concluded that acamprosate modulates the endogenous opioid system.
本研究的目的是评估反复给予阿坎酸（治疗酒精中毒最有效的药物之一）后，华沙低偏好（WLP）大鼠和华沙高偏好（WHP）大鼠的血浆β-内啡肽水平。以200mg/kg的剂量口服阿坎酸治疗10天可导致血浆β-内啡肽水平升高。单次注射乙醇也会导致β-内啡肽水平升高。此外，研究发现，对先前用阿坎酸治疗过的WHP大鼠单次注射乙醇，其血浆β-内啡肽含量的升高幅度较低。在WLP大鼠中，反复给予阿坎酸可预防乙醇诱导的血浆β-内啡肽水平升高。可以得出结论，阿坎酸可调节内源性阿片系统。
