Copp M V, Hill A J, Feneck R O
London Chest Hospital, United Kingdom.
Eur J Anaesthesiol Suppl. 1992;5:35-41.
We have reviewed the current data evaluating the effects of intravenous milrinone in patients following cardiac surgery. Milrinone has been shown to be effective in the treatment of acute low output syndrome, and a loading bolus infusion of 50 micrograms kg-1 over 10 min causes an increase in cardiac index and a fall in pulmonary capillary wedge pressure. These effects are easily maintained by a continuous infusion regimen. Other haemodynamic effects are seen, including systemic and pulmonary vasodilatation and an increase in heart rate. These effects are not confined to one patient group, but the increase in cardiac index does appear to be more pronounced in those patients with poor haemodynamics prior to treatment. There is a low incidence of adverse events including arrhythmias and hypotension. Thus milrinone appears to be well tolerated in a broad group of adult patients recovering from cardiac surgery.
我们回顾了当前评估静脉注射米力农对心脏手术后患者影响的数据。米力农已被证明在治疗急性低输出量综合征方面有效，在10分钟内静脉推注50微克/千克可使心脏指数增加，肺毛细血管楔压降低。通过持续输注方案可轻松维持这些效果。还可见到其他血流动力学效应，包括全身和肺血管扩张以及心率增加。这些效应并不局限于某一组患者，但在治疗前血流动力学较差的患者中，心脏指数的增加似乎更为明显。不良事件的发生率较低，包括心律失常和低血压。因此，米力农在从心脏手术中恢复的广大成年患者中似乎耐受性良好。
