George M, Lehot J J, Estanove S
Hôpital Cardiovasculaire L. Pradel, Lyon, France.
Eur J Anaesthesiol Suppl. 1992;5:31-4.
The haemodynamic and biological effects of intravenous milrinone were studied in 24 adult patients with a low cardiac output syndrome following cardiac surgery. The patients received a milrinone bolus of 50 micrograms kg-1 over 10 min followed by a 0.375-0.750 micrograms kg-1 min-1 infusion over 48 h. After the first hour of treatment, an increase in cardiac index, systolic index and left ventricular stroke work index, and a decrease in right and left loading pressures, pulmonary artery pressure, systemic vascular resistance and pulmonary vascular resistance were observed while heart rate and systemic arterial pressure were not modified. These haemodynamic effects were maintained over the 48 h of treatment and persisted 3 h after discontinuation of treatment. Milrinone, which possesses inotropic and vasodilatory effects, increased cardiac performance and corrected the low cardiac output in all patients.
对24例心脏手术后出现低心排血量综合征的成年患者，研究了静脉注射米力农的血流动力学和生物学效应。患者在10分钟内接受50微克/千克的米力农推注，随后在48小时内以0.375 - 0.750微克/千克·分钟的速度输注。治疗1小时后，观察到心脏指数、收缩指数和左心室每搏功指数增加，右、左负荷压力、肺动脉压、体循环血管阻力和肺血管阻力降低，而心率和体循环动脉压未改变。这些血流动力学效应在治疗的48小时内持续存在，并在停药后持续3小时。米力农具有正性肌力和血管舒张作用，可提高所有患者的心脏功能并纠正低心排血量。
