Aydin Omer, Ustündağ Emre, Boyaci Zerrin, Müezzinoğlu Bahar
Department of Otolaryngology, Medicine Faculty of Kocaeli University, Kocaeli, Turkey.
Kulak Burun Bogaz Ihtis Derg. 2004;12(3-4):103-6.
Skin metastasis from laryngeal carcinoma is rare and indicates a poor prognosis. A case of laryngeal carcinoma with unusual metastasis to the skin of the hand is reported. The patient underwent total laryngectomy, left radical neck dissection, and right functional neck dissection. After the operation, the patient received radiotherapy. In the postoperative 18th month, a mass was observed in the left hand. It was found to be a metastatic tumor from laryngeal carcinoma, histopathologically as well as immunohistochemically. Metastatic potential in malignant neoplasms is generally correlated with reduced cellular adhesiveness. We investigated the expression of the vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), and E-cadherin. Interestingly, the immunohistochemical expression characteristics of such an aggressive tumor were not positive.
喉癌皮肤转移罕见且预后不良。本文报告1例喉癌发生罕见的手部皮肤转移病例。患者接受了全喉切除术、左侧根治性颈清扫术和右侧功能性颈清扫术。术后患者接受了放疗。术后第18个月，左手发现肿物。经组织病理学及免疫组织化学检查，确诊为喉癌皮肤转移瘤。恶性肿瘤的转移潜能通常与细胞黏附性降低相关。我们检测了血管内皮生长因子（VEGF）、基质金属蛋白酶-9（MMP-9）和E-钙黏蛋白的表达。有趣的是，这种侵袭性肿瘤的免疫组织化学表达特征并非阳性。
