Moresco R M, Fazio F
IBFM-CNR, Scientific Institute San Raffaele, University of Milan-Bicocca, San Raffaele Hospital, Via Olgettina 60, 20132 Milan, Italy.
Q J Nucl Med Mol Imaging. 2005 Jun;49(2):205-14.
Positron emission tomography (PET) and single photon emission tomography (SPET) permit the in vivo assessment of human biological processes with methods originally developed for preclinical studies. This opportunity is of primary interest in biological psychiatry and in psychoactive drugs development. Most of research efforts have focused on the use of PET field, and several biological finding on central nervous system (CNS) diseases have been published. Despite methodological limitations, the feasibility and usefulness of SPET for research, including full quantification, kinetic modeling and tracer validation, has been clearly demonstrated. The aim of this paper is to review advantages, limitations and results of SPET in psychopharmacology.
正电子发射断层扫描（PET）和单光子发射断层扫描（SPET）能够通过最初为临床前研究开发的方法对人体生物过程进行体内评估。这一机遇在生物精神病学和精神活性药物研发中具有至关重要的意义。大部分研究工作都集中在PET领域的应用上，并且已经发表了一些关于中枢神经系统（CNS）疾病的生物学研究成果。尽管存在方法学上的局限性，但SPET在研究中的可行性和实用性，包括全定量、动力学建模和示踪剂验证等方面，已得到明确证实。本文旨在综述SPET在精神药理学中的优势、局限性及研究结果。
