Boddy J L, Pike D J, Al-Hayek S, Shaida N, Malone P R
The Harold Hopkins Department of Urology, Royal Berkshire Hospital, Reading, UK.
Prostate Cancer Prostatic Dis. 2005;8(4):349-52. doi: 10.1038/sj.pcan.4500819.
The purpose of this study was to determine the incidence of prostate cancer in patients who have an elevated referral prostate-specific antigen (PSA), which subsequently falls to within their normal age-specific reference range prior to prostate biopsy. The study demonstrated that of the 160 patients recruited, 21 (13%) had a repeat PSA level which had fallen back to within their normal range. Five of these 21 patients (24%) were diagnosed with prostate cancer following biopsy, two of whom had a benign prostate examination. The study, therefore, demonstrates that normalisation of the PSA level prior to biopsy does not exclude the presence of prostate cancer even when the prostate feels benign.
本研究的目的是确定转诊时前列腺特异性抗原（PSA）升高、随后在前列腺活检前降至其特定年龄正常参考范围内的患者中前列腺癌的发病率。该研究表明，在招募的160名患者中，有21名（13%）的PSA重复检测水平已回落至正常范围内。这21名患者中有5名（24%）在活检后被诊断为前列腺癌，其中两名患者前列腺检查结果为良性。因此，该研究表明，活检前PSA水平正常化并不排除前列腺癌的存在，即使前列腺检查结果为良性。
