氰病毒-N与甘露糖α1-2甘露糖功能化树枝状大分子的结合。
Cyanovirin-N binding to Manalpha1-2Man functionalized dendrimers.
作者信息
Mangold Shane L, Morgan Joel R, Strohmeyer Gregory C, Gronenborn Angela M, Cloninger Mary J
机构信息
Department of Chemistry and Biochemistry and Center for Bioinspired Nanomaterials, 108 Gaines Hall, Montana State University, Bozeman, MT 59717, USA.
出版信息
Org Biomol Chem. 2005 Jun 21;3(12):2354-8. doi: 10.1039/b417789d. Epub 2005 May 24.
Manalpha1-2Man functionalized G(3) and G(4)-PAMAM dendrimers have been synthesized and characterized by MALDI-TOF MS and NMR spectroscopy. Precipitation assays to assess the binding of the dimannose-functionalized dendrimers to Cyanovirin-N, a HIV-inactivating protein that blocks virus-to-cell fusion through high mannose mediated interactions, are presented.
已合成了带有Manα1-2Man功能化的G(3)和G(4)-聚酰胺-胺（PAMAM）树枝状大分子，并通过基质辅助激光解吸电离飞行时间质谱（MALDI-TOF MS）和核磁共振光谱（NMR）对其进行了表征。本文展示了沉淀试验，以评估双甘露糖功能化树枝状大分子与氰苷菌素-N的结合，氰苷菌素-N是一种可使HIV失活的蛋白质，它通过高甘露糖介导的相互作用来阻断病毒与细胞的融合。
Zotero 插件